Strategies for the synthesis of brevipolides

• Yudhi D. Kurniawan and
• A'liyatur Rosyidah

Beilstein J. Org. Chem. 2021, 17, 2399–2416, doi:10.3762/bjoc.17.157

• revealed various results, including toxicity to brine shrimp [9], DNA intercalation as well as antibacterial and fungal [4][9], and strong insecticidal activity against the 3rd instar larva of the cotton leaf worm Spodoptera littoralis (Biosd.) [7]. The essential oil extracted from the leaf of Hyptis

Natural products in the predatory defence of the filamentous fungal pathogen Aspergillus fumigatus

• Jana M. Boysen,
• Nauman Saeed and
• Falk Hillmann

Beilstein J. Org. Chem. 2021, 17, 1814–1827, doi:10.3762/bjoc.17.124

• fungi also produce compounds with antibacterial, antifungal and insecticidal properties to ward of both competitors and predators. The mycotoxins aflatoxin B1 (1) from Aspergillus flavus and patulin (2), produced by Aspergillus and Penicillium species, exhibit insecticidal activity against Drosophila

Semi-synthesis and insecticidal activity of spinetoram J and its D-forosamine replacement analogues

• Kai Zhang,
• Jiarong Li,
• Honglin Liu,
• Haiyou Wang and
• Lamusi A

Beilstein J. Org. Chem. 2018, 14, 2321–2330, doi:10.3762/bjoc.14.207

• applied in pest control and crop protection due to their broad pest spectrum, high insecticidal activity, low environmental impact, and low toxicity to non-target species [4]. So far, more than 24 natural spinosyns and 800 semi-synthetic spinosyn analogues have been obtained and characterized, and their

• change when the sugar constituents are altered. Previous studies have shown that modification of the spinosyn structure could potentially improve insecticidal activity and expand the insect spectrum [20][21]. Indeed, a large number of researchers have altered spinosad, replacing rhamnose or D-forosamine

• BF3·(C2H5)2O under Ar gas. Due to the high yields and few byproducts in the synthesis of glycoside donors, the donors could be used directly in the glycosylation without purification. Insecticidal activity The insecticidal activities of synthetic spinetoram J and its analogues were evaluated using

A semisynthesis of 3'-O-ethyl-5,6-dihydrospinosyn J based on the spinosyn A aglycone

• Kai Zhang,
• Shenglan Liu,
• Anjun Liu,
• Hongxin Chai,
• Jiarong Li and
• Lamusi A

Beilstein J. Org. Chem. 2017, 13, 2603–2609, doi:10.3762/bjoc.13.257

• analogues which may have more efficient insecticidal activity [23][24][25][26]. This study offers a novel approach to synthesize spinosyn analogues. Results and Discussion Hydrolysis of spinosyn A and famation of aglycone and D-forosamine As reported [27], both aglycone and D-forosamine are the hydrolysis

Multicomponent reactions: A simple and efficient route to heterocyclic phosphonates

• Mohammad Haji

Beilstein J. Org. Chem. 2016, 12, 1269–1301, doi:10.3762/bjoc.12.121

• -aminophosphonates 36 in good yields (Scheme 10). Some of the resulting α-aminophosphonates showed insecticidal activity against Plutella xylostella [36]. An asymmetric synthesis of heterocyclic α-aminophosphonates has been reported by Fadel et al. [37]. Their studies showed that the three-component reaction of N

Natural products from microbes associated with insects

• Christine Beemelmanns,
• Huijuan Guo,
• Maja Rischer and
• Michael Poulsen

Beilstein J. Org. Chem. 2016, 12, 314–327, doi:10.3762/bjoc.12.34

• amino acid residues, and they exhibit a wide range of interesting biological properties, such as insecticidal, cytotoxic, and moderate antibiotic activity [128]. The secretion of destruxins is weakly correlated to fungal virulence and insecticidal activity, because injection, ingestion or topical

Synthesis, antimicrobial and cytotoxicity evaluation of new cholesterol congeners

• Mohamed Ramadan El Sayed Aly,
• Hosam Ali Saad and
• Shams Hashim Abdel-Hafez

Beilstein J. Org. Chem. 2015, 11, 1922–1932, doi:10.3762/bjoc.11.208

• able to disrupt the cholesterol-rich lipid envelope and inactivate viral invasion [17]. Cholesterol-based hydrazones exhibited insecticidal activity against the larval stage of Mythimna separate (Walker) [18]. Cholesterol–carbamate conjugates, for instance (3β)-cholest-5-en-3-yl (2-aminoethyl)carbamate

Synthesis of chiral sulfoximine-based thioureas and their application in asymmetric organocatalysis

• Marcus Frings,
• Isabelle Thomé and
• Carsten Bolm

Beilstein J. Org. Chem. 2012, 8, 1443–1451, doi:10.3762/bjoc.8.164

• dimethylsulfoximine [50]. The chemistry of the resulting thiourea-like compounds, however, has remained rather unexplored until now. Only two patents from Dow Agrosciences report syntheses of related structures, their use as intermediate products, and their insecticidal activity [51][52]. Furthermore, only achiral or

Identification and isolation of insecticidal oxazoles from Pseudomonas spp.

• Florian Grundmann,
• Veronika Dill,
• Andrea Dowling,
• Aunchalee Thanwisai,
• Edna Bode,
• Narisara Chantratita,
• Richard ffrench-Constant and
• Helge B. Bode

Beilstein J. Org. Chem. 2012, 8, 749–752, doi:10.3762/bjoc.8.85

• intermediates were also investigated revealing interesting biological activities for several compounds despite their overall simple structures. Keywords: insecticidal activity; labradorin; oxazole; Pseudomonas; secondary metabolite; Findings During our search for novel natural products from entomopathogenic

• to the overall insecticidal activity of the investigated Pseudomonas strains. Structures of pseudopyronines A (1) and B (2) and natural oxazoles (3–8) as well as synthetic oxazole derivatives (9–11). All natural and synthetic oxazoles show the characteristic MS fragment 130 m/z [M + H]+. The

Synthesis of szentiamide, a depsipeptide from entomopathogenic Xenorhabdus szentirmaii with activity against Plasmodium falciparum

• Friederike I. Nollmann,
• Andrea Dowling,
• Marcel Kaiser,
• Klaus Deckmann,
• Sabine Grösch,
• Richard ffrench-Constant and
• Helge B. Bode

Beilstein J. Org. Chem. 2012, 8, 528–533, doi:10.3762/bjoc.8.60

• biological activity against insect cells and protists such as P. falciparum. The rationale behind this bioactivity may be that 1 adds to the overall insecticidal activity of Xenorhabdus bacteria. Protists such as amoeba are common soil inhabitants, which may feed on the dead insect cadaver. Thus, compounds

Recent progress on the total synthesis of acetogenins from Annonaceae

• Nianguang Li,
• Zhihao Shi,
• Yuping Tang,
• Jianwei Chen and
• Xiang Li

Beilstein J. Org. Chem. 2008, 4, No. 48, doi:10.3762/bjoc.4.48

• synthesis of annonin I and asiminacin Among the 19 ACGs that were isolated from Annona squamosa Born’s group found annonin I (181a) [74] to be the most potent compound concerning cytotoxic and insecticidal activity. With the aim to prepare interesting substances for biological assays, Scharf’s group

Development of potential manufacturing routes for substituted thiophenes – Preparation of halogenated 2-thiophenecarboxylic acid derivatives as building blocks for a new family of 2,6-dihaloaryl 1,2,4-triazole insecticides

• John W. Hull Jr.,
• Duane R. Romer,
• David E. Podhorez,
• Mezzie L. Ash and
• Christine H. Brady

Beilstein J. Org. Chem. 2007, 3, No. 23, doi:10.1186/1860-5397-3-23

• lost to insects. [2] Dow AgroSciences has been investigating a new family of functionalized 2,6-dihaloaryl 1,2,4-triazole insecticides featuring specifically targeted insecticidal activity coupled with low mammalian toxicity. [3][4][5][6] With broad spectrum control of both chewing and sap-feeding